Advances in programming synthesis and designof nanomaterials along with advances in genomics and tissue engineering were built-in for efficient control ofbone healing and orthopedic technology. Porous implant substrates have been developed as bone defect augmentation and drugcarriersystems. Nanotechnology has been utilized in synthesis of scaffolds, birth mechanisms, managed modification ofsurface topography and composition, and biomicroelectromechanical procedures, that are promising for bone healing and tissueengineering. This is programming second part of issue which is related programmers current trends in enzyme inhibition and dockinganalysis in drug design. The topics supplied address characterization of Pseudomonas aeruginosa glucose 6 phosphateisomerase, analyses towards M. tuberculosis enzyme goals, antimicrobial recreation of isoindole 3 1,1 dioxide derivatives, docking assisted prediction of programming mechanism of action of expertise inhibitors ofprotein tyrosine phosphate PTP1B in opposition t type II diabetes mellitus, and wide review on RASinhibition in addition to ATP synthase inhibitors as anti tubercular agents.